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Curriculum Alignments

Connecting Game Content to Curriculum
Although the curriculum content you are responsible for varies among regions, aspects of your curriculum can be found within the game. Below are select content requirements that are found in a number of biology curricula. Remind students that while they are playing the game they should be looking for the content that they are responsible for learning.

Basic Training:

  • The general composition of blood.
  • Identifying some major cell types of the immune system

Game 1: Monocyte to Macrophage:

  • What are leukocytes (white blood cells)?
  • What is a macrophage and what does it do?
  • Macrophages can travel to a site of infection.
  • How leukocytes can move from the blood stream into the tissue.

Game 2: Follow the Chemical Trail:

  • Some immune cells can follow chemical trials
  • Some of these chemicals are released from bacteria. Other chemical signals are released from wounded body tissue

Game 3: Recognize the Enemy:
What is meant by “self” and “non-self?”

  • Macrophages must be activated to kill bacteria.

Game 4: Eat the Pseudomonas:

  • Macrophages kill bacteria by eating them through a process called phagocytosis.

Game 5: Call the Neutrophil

  • What is a neutrophil and what does it do?
  • Neutophils must be called to the site of infection through a chemical signal (CXCL8).
  • Neutrophils can eat bacteria

Game 6: Eat the Staphyloccocus

  • Are all bacteria the same?
  • How the immune systems deals with two different types of pathogenic bacteria.

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