NOTE: To jump to a particular place in the game or make your nanobot invincible, use the Instructor Menu at the start up screen. Type abc at password prompt, and then select a starting point:
- Story Intro and Basic Training
- Game 1: Monocyte to Macrophage (Transmigration)
- Enter the Connective Tissue
- Game 2: Follow the Chemical Trail (of C3a)
- Game 3: Recognize the Enemy (Activate LPS Receptors)
- Game 4: Eat the Pseudomonas!
- Introducing The Neutrophil
- Game 5: Call the Neutrophil to the Site of Infection (Activate CXCL8)
- Game 6: Transfer Abilities to Neutrophils
- Game 7: Eat the Staphyloccocus
Our protagonist’s immune system is non-functional.
Basic Training: Navigation
Learn to control the nanobot.
Train monocytes to transmigrate out of the blood vessel network
and pass into the connective tissue.
- Activate 6 selectins to slow down the monocyte.
- Activate 1 ICAM to stop the monocyte and initiate transmigration.
- Watch the monocyte pass through the blood vessel wall and enter the
- Repeat above steps for second monocyte.
Train the macrophage to follow the chemical trail of C3as leading to the site of infection (the Pseudomonas bacteria).
- Mark a path of C3as leading to the bacteria.
Train the macrophage to recognize the Pseudomonas bacteria.
- Mark 10 LPS receptors on the macrophage.
Target the Pseudomonas cells and watch the macrophage eat them!
- Mark all of the Pseudomonas cells.
Introducing the Neutrophil
What is a neutrophil?
Call for neutrophil back up by releasing CXCL8 chemical signals.
- Mark seven CXCL8 molecules on the macrophage. They will release a CXCL8 chemical signal.
Game 6: Transfer Abilities to Neutrophils
Train the neutrophil by transferring abilities from the macrophage.
- Click on each of the small circles to transfer transmigration, follow the chemical trail, and eating skills.
Train the neutrophil to recognize and attack the Staphylococcus.
- Mark all of the Staphylococcus cells.